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. Author manuscript; available in PMC: 2017 Aug 24.
Published in final edited form as: Sci Transl Med. 2016 Aug 24;8(353):353ra111. doi: 10.1126/scitranslmed.aaf7483

Fig. 5.

Fig. 5

Pro-resolving lipid mediators promote de novo generation of Foxp3-expressing Treg cells. (A) Schematic representation of iTreg generation. (B) Flow cytometry analysis of iTreg cells gated on CD4+CD25high and CD127- cells and expressing Foxp3, CTLA-4 and Granzyme B, and ELISA of IL-10 in supernatants of iTreg cells. Data are shown as means ± SEM of four independent experiments. *p <0.05 versus iTreg, **p <0.01 versus iTreg (one-way Anova). (C) Percentages of intracellular expression of Foxp3 in CD25high CD4+ T cells of splenocytes obtained from wild type (WT), Elovl2 knock out (Elovl2−/−) and Elovl2−/− + DHA mice. Data are shown as means ± SEM of 5 different mice. *p <0.05 versus WT, #p <0.05 versus Elovl2−/−(one-way Anova).