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. Author manuscript; available in PMC: 2017 Nov 9.
Published in final edited form as: Cell Host Microbe. 2016 Oct 27;20(5):596–605. doi: 10.1016/j.chom.2016.10.003

Fig. 6. Defective PMN responses and bacterial clearance in the IL-17RC epithelial conditional KO mice.

Fig. 6

WT or Il17re+/− as well as littermates Il17re−/− mice were infected with 104 KP-43816 intranasally and sacrificed 24h post infection. Bacterial burden in the lungs were determined by standard CFU assay (A). See also supplementary Fig. 6. C57BL/6 mice were challenged with recombinant IL-17C (500ng/mouse) with or without IL-17RE Fc (500ng/mouse) intranasally and sacrificed at 24h. BAL neutrophils and macrophage numbers were determined by FACS (B). C57BL/6 mice were infected with 104 KP43816 intranasally with or without IL-17RE Fc (500ng/mouse) intranasally and sacrificed at 24h. Bacterial burden in the lungs were determined by CFU (C) and gene expression in the lungs were analyzed by real-time RT-PCR (D). Littermate controls as well as Il17rcfl/fl and Il17rcfl/fl Scgb1a1-Cre+ mice were infected with 105 KP-2146 intranasally and sacrificed 24h post infection. Bacterial burden in the lungs were determined by CFU (E). Data are represented as mean +/− SEM.