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. Author manuscript; available in PMC: 2017 Jan 29.
Published in final edited form as: Mod Pathol. 2016 Jul 29;29(11):1370–1380. doi: 10.1038/modpathol.2016.122

Table 3.

Correlation between β-catenin mutation and β-catenin nuclear staining with the glutamine synthetase staining pattern in hepatocellular tumors.

Glutamine
synthetase
staining
Typical hepatocellular
adenoma (n=15)
Atypical hepatocellular
neoplasm (n=5)
Hepatocellular carcinoma
(n=60)
β-catenin
mutated (%)
β-catenin
nuclear (%)
β-catenin
mutated (%)
β-catenin
nuclear (%)
β-catenin
mutated (%)
β-catenin
nuclear (%)

Patchy glutamine
synthetase
0/9 0/9 0/1 0/1 2/13 (15) 0/13

Diffuse
glutamine
synthetase-all
2/6 (33) 2/6 (33) 3/4 (75) 0/4 8/47 (17) 18/47 (38)

Diffuse glutamine
synthetase -
homogeneous
pattern only
0/2 0/2 1/1 (100) 0/1 5/19 (26) 14/19 (74)

Diffuse glutamine
synthetase -
heterogeneous
pattern only
2/4 (50) 2/4 (50) 2/3 (67) 0/3 3/28 (11) 4/28 (14)