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. 2004 Jul 1;23(14):2892–2902. doi: 10.1038/sj.emboj.7600278

Figure 7.

Figure 7

Pax6 and Tlx cooperate during late corticogenesis (E18.5) to specify neuronal phenotypes. (A–D) Math2 expression in the CP and IZ was lost in small clusters in Tlx mutant IZ, and in large regions of the IZ in Pax6 and Pax6;Tlx mutants (asterisks, insets, B–D), but was maintained in the upper CP (arrowheads, C, D). (E–H) Dlx1 was expressed in migrating cortical interneurons in the GZ, MZ and CP (E), in small ectopic clusters in the GZ of Tlx mutants, and in a grossly expanded GZ in Pax6 and Pax6;Tlx mutants (asterisks, F–H). (I–L) Layer VI expression of Tbr1 was maintained in all genotypes (arrowheads, K, L). (M–P) ER81 was expressed in layer V in all genotypes (arrowheads, O, P) and ectopically expressed in the IZ of Tlx mutants, and SVZ/IZ of Pax6 and Pax6;Tlx mutants (asterisks, N–P). (Q–T) Layer IV expression of ROR-β was lost in rostral CP of Pax6;Tlx mutants (arrows, T), but maintained in Pax6 mutants (arrowheads, S). Layers II–IV expression of Oct6 (U–X) and Cux1 (Y-BB) was detected, albeit at decreased levels, in Pax6 mutants (arrowheads, W; arrows, AA), but was not expressed in rostral CP of Pax6;Tlx double mutants (arrows, X, BB). gz, germinal zone; uc, upper CP; lc, lower CP; iz, intermediate zone.