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. 2016 Dec 12;6:181. doi: 10.3389/fcimb.2016.00181

Figure 2.

Figure 2

Impact of vaccination on mouse survival after pulmonary challenge with ETEC. (A) Mouse survival is plotted as a function of time (h) after mice were inoculated with the indicated ETEC strains following intranasal immunization with the indicated antigens, n = 10–15. Asterisks indicate significantly different (p < 0.05) mouse survival, log-rank test. (B) ETEC loads (CFUs/g lung) in mice infected with the indicated ETEC strains at time of euthanasia or at the end of the study (7 d). Open symbols indicate mice that survived for the duration of the study. Closed symbols indicate mice that were euthanized due to their display of clinical signs of illness, n = 10–15. Asterisks indicate significantly different (p < 0.05) ETEC loads in mouse lungs, Kruskal-Wallis test. (C) Fold change in mouse fecal IgA concentrations after immunization with the indicated antigens. Open symbols indicate mice that survived for the duration of the study. Closed symbols indicate mice that were euthanized due to their display of clinical signs of illness. n = 10. Asterisks indicate significantly different (p < 0.05) fecal IgA concentrations, Kruskal-Wallis test.