Table 2.
Patient and tumor characteristics of all patients undergoing BCS with available resection margin status (n = 25,311)
| Total (n = 25.311) | Margin free or focally irradical | Margin more than focally irradical | OR, univariate analysis (95 % CI) | OR, multivariate analysis (95 % CI) | |
|---|---|---|---|---|---|
| Age at diagnosis, no (%) | |||||
| <50 | 4390 | 4010 (91.34) | 380 (8.66) | 1.53 (1.35–1.74) | 1.22 (1.00–1.49) |
| 50–59 | 7085 | 6607 (93.25) | 478 (6.75) | 1.17 (1.04–1.31) | 1.01 (0.85–1.20) |
| ≥60 | 13836 | 13029 (94.17) | 807 (5.83) | 1.0 (ref) | 1.0 (ref) |
| Multifocality, no (%) | |||||
| Yes | 773 | 637 (82.41) | 136 (17.59) | 3.25 (2.68–3.95) | 2.82 (2.14–3.71) |
| No | 19911 | 18685 (93.84) | 1226 (6.16) | 1.0 (ref) | 1.0 (ref) |
| Missing | 4627 | ||||
| Tumor type, no(%) | |||||
| Ductal | 21143 | 19889 (94.07) | 1254 (5.93) | 1.0 (ref) | 1.0 (ref) |
| Lobular | 2344 | 2039 (86.99) | 305 (13.01) | 2.37 (2.08–2.71) | 3.12 (2.48–3.92) |
| Other | 1824 | 1718 (94.19) | 106 (5.81) | 0.98 (0.80–1.20) | 1.18 (0.88–1.58) |
| Tumor size, no (%) | |||||
| ≤2 cm | 19816 | 18807 (94.91) | 1009 (5.09) | 1.0 (ref) | 1.0 (ref) |
| >2–≤5 cm | 5351 | 4754 (88.84) | 597 (11.16) | 2.34 (2.11–2.60) | 2.01 (1.71–2.37) |
| >5 cm | 144 | 85 (59.03) | 59 (40.97) | 12.95 (9.24–18.16) | 12.30 (7.12–21.26) |
| Tumor grade, no (%) | |||||
| 1 | 6720 | 6401 (95.25) | 319 (4.75) | 1.0 (ref) | 1.0 (ref) |
| 2 | 9747 | 9032 (92.66) | 715 (7.34) | 1.59 (1.39–1.82) | 1.19 (0.99–1.43) |
| 3 | 5108 | 4768 (93.34) | 340 (6.66) | 1.43 (1.22–1.68) | 1.03 (0.81–1.31) |
| Missing | 3736 | ||||
| Estrogen receptor status, no (%) | |||||
| Positive (≥10%) | 21182 | 19739 (93.19) | 1443 (6.81) | 1.0 (ref) | 1.0 (ref) |
| Negative (<10%) | 3130 | 2962 (94.63) | 168 (5.37) | 0.78 (0.66–0.92) | 0.94 (0.72–1.21) |
| Missing | 999 | ||||
| Progesterone receptor status, no (%) | |||||
| Positive (≥10%) | 16769 | 15654 (93.35) | 1115 (6.65) | 1.0 (ref) | |
| Negative (<10%) | 7518 | 7024 (93.43) | 494 (6.57) | 0.99 (0.89–1.10) | |
| Missing | 1024 | ||||
| Her2 status, no (%) | |||||
| Positive | 2152 | 1972 (91.64) | 180 (8.36) | 1.0 (ref) | 1.0 (ref) |
| Negative | 20416 | 19094 (93.52) | 1322 (6.48) | 0.76 (0.65–0.89) | 0.82 (0.64–1.05) |
| Missing | 2743 | ||||
| Angio-invasion, no (%) | |||||
| Yes | 1784 | 1581 (88.62) | 203 (11.38) | 2.02 (1.72–2.37) | 1.63 (1.33–2.01) |
| No | 16105 | 15142 (94.02) | 963(5.98) | 1.0 (ref) | 1.0 (ref) |
| Missing | 7422 | ||||
| Presence of DCIS, no (%) | |||||
| Yes | 11233 | 10205 (90.85) | 1028 (9.15) | 2.13 (1.91–2.35) | 2.71 (2.29–3.22) |
| No | 14078 | 13441 (95.48) | 637 (4.52) | 1.0 (ref) | 1.0 (ref) |
| DCIS outside invasive component, no (%) | |||||
| Yes | 3694 | 3251 (88.01) | 443 (11.99) | 2.42 (2.01–2.92) | |
| No | 3037 | 2875 (94.67) | 162 (5.33) | 1.0 (ref) | |
| Missing | 4502 | ||||
| Diameter of DCIS, no (%) | |||||
| ≤2 cm | 5594 | 5262 (94.07) | 332 (5.93) | 1.0 (ref) | |
| >2–≤5 cm | 1526 | 1215 (79.62) | 311 (20.38) | 4.06 (3.43–4.79) | |
| >5 cm | 196 | 125 (63.78) | 71 (36.22) | 9.00 (6.59–12.30) | |
| Missing | 3917 | ||||