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. 2016 Dec 12;2:16081. doi: 10.1038/cddiscovery.2016.81

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Copyright © 2016 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The antitumor effect of hvTRA, vemurafenib and the combination in vivo. Melmet 5 xenografts were treated with hvTRA () (3 mg/kg, i.v. injection) or vemurafenib () 50 mg/kg, orally twice a day) or the combination of hvTRA and vemurafenib (). The treatment schedule is indicated in the figure by and . The tumors were measured twice or thrice a week using a caliper, and are presented as relative tumor volume related to the volume of the tumor at the initiation of the treatment. Eight tumors are included in each group. Error bars represent ±S.E.M.

Inline graphic — The antitumor effect of hvTRA, vemurafenib and the combination in vivo. Melmet 5 xenografts were treated with hvTRA () (3 mg/kg, i.v. injection) or vemurafenib () 50 mg/kg, orally twice a day) or the combination of hvTRA and vemurafenib (). The treatment schedule is indicated in the figure by and . The tumors were measured twice or thrice a week using a caliper, and are presented as relative tumor volume related to the volume of the tumor at the initiation of the treatment. Eight tumors are included in each group. Error bars represent ±S.E.M.