Table 2.
PCE frequencies from dams of rat study groups at the different sampling times.
| Groups | 0 h | 24 h | 48 h | 72 h | 96 h | 120 h |
|---|---|---|---|---|---|---|
| Negative control | 78.00 ± 27.17 | 84.20 ± 29.77 | 79.60 ± 25.40 | 88.00 ± 23.39 | 81.80 ± 23.42 | 89.40 ± 22.43 |
| ∗NS | ∗NS | ∗NS | ∗NS | ∗NS | ||
|
| ||||||
| CP lower-dose | 83.20 ± 20.33 ∗∗NS | 82.20 ± 53.89 | 82.20 ± 45.06 | 83.40 ± 46.95 | 80.60 ± 30.66 | 86.60 ± 46.12 |
| ∗NS | ∗NS | ∗NS | ∗NS | ∗NS | ||
| ∗∗NS | ∗∗NS | ∗∗NS | ∗∗NS | ∗∗NS | ||
|
| ||||||
| CP middle-dose | 74.60 ± 23.33 ∗∗NS | 84.40 ± 37.66 | 78.80 ± 58.31 | 68.80 ± 41.15 | 76.20 ± 23.84 | 83.40 ± 30.30 |
| ∗NS | ∗NS | ∗NS | ∗NS | ∗NS | ||
| ∗∗NS | ∗∗NS | ∗∗NS | ∗∗NS | ∗∗NS | ||
|
| ||||||
| CP higher-dose | 77.40 ± 10.71 ∗∗NS | 56.40 ± 19.83 | 48.80 ± 19.86 | 34.40 ± 16.41 | 30.20 ± 17.02 | 44.20 ± 16.97 |
| ∗NS | ∗NS | ∗ P = 0.037 | ∗ P = 0.047 | ∗NS | ||
| ∗∗NS | ∗∗NS | ∗∗ P = 0.003 | ∗∗ P = 0.004 | ∗∗ P = 0.007 | ||
|
| ||||||
| COL lower-dose | 90.80 ± 44.42 ∗∗NS | 100.00 ± 60.46 | 92.00 ± 45.91 | 93.20 ± 43.89 | 99.00 ± 49.40 | 97.20 ± 57.93 |
| ∗NS | ∗NS | ∗NS | ∗NS | ∗NS | ||
| ∗∗NS | ∗∗NS | ∗∗NS | ∗∗NS | ∗∗NS | ||
|
| ||||||
| COL middle-dose | 87.20 ± 42.71 ∗∗NS | 97.40 ± 52.79 | 105.60 ± 54.24 | 129.00 ± 38.40 | 106.00 ± 37.28 | 102.40 ± 60.16 |
| ∗NS | ∗NS | ∗NS | ∗NS | ∗NS | ||
| ∗∗NS | ∗∗NS | ∗∗NS | ∗∗NS | ∗∗NS | ||
|
| ||||||
| COL higher-dose | 81.80 ± 28.09 ∗∗NS | 99.60 ± 63.70 | 89.40 ± 38.37 | 131.40 ± 61.67 | 119.40 ± 43.84 | 97.00 ± 39.86 |
| ∗NS | ∗NS | ∗NS | ∗NS | ∗NS | ||
| ∗∗NS | ∗∗NS | ∗∗NS | ∗∗NS | ∗∗NS | ||
|
| ||||||
| AraC lower-dose | 83.40 ± 23.44 ∗∗NS | 95.80 ± 56.98 | 99.60 ± 52.55 | 94.80 ± 60.72 | 105.00 ± 61.70 | 105.60 ± 76.51 |
| ∗NS | ∗NS | ∗NS | ∗NS | ∗NS | ||
| ∗∗NS | ∗∗NS | ∗∗NS | ∗∗NS | ∗∗NS | ||
|
| ||||||
| AraC middle-dose | 82.60 ± 24.78 ∗∗NS | 82.20 ± 28.38 | 103.40 ± 65.58 | 106.60 ± 62.77 | 95.80 ± 41.43 | 102.40 ± 38.41 |
| ∗NS | ∗NS | ∗NS | ∗NS | ∗NS | ||
| ∗∗NS | ∗∗NS | ∗∗NS | ∗∗NS | ∗∗NS | ||
|
| ||||||
| AraC higher-dose | 82.20 ± 26.48 ∗∗NS | 86.00 ± 49.10 | 95.00 ± 35.62 | 83.80 ± 34.60 | 98.80 ± 51.84 | 89.60 ± 22.22 |
| ∗NS | ∗NS | ∗NS | ∗NS | ∗NS | ||
| ∗∗NS | ∗∗NS | ∗∗NS | ∗∗NS | ∗∗NS | ||
Data (‰) expressed as mean ± standard deviation per group of PCEs/1,000 TEs. PCEs: polychromatic erythrocytes, TEs: total erythrocytes, h: hours, and NS: not significant. ∗Intragroup comparisons. ∗∗Intergroup comparisons between negative control groups versus the other groups.