Table 3.
MNE frequencies from pup samples of rat study groups at different sampling times.
| Groups | 0 h | 24 h | 48 h | 72 h | 96 h | 120 h |
|---|---|---|---|---|---|---|
| Negative control | 2.25 ± 0.6 | 2.34 ± 0.5 | 2.48 ± 0.7 | 2.37 ± 0.6 | 2.55 ± 0.6 | 2.51 ± 0.7 |
| ∗NS | ∗NS | ∗NS | ∗NS | ∗NS | ||
|
| ||||||
| CP lower-dose | 2.21 ± 0.3 ∗∗NS | 2.77 ± 0.6 | 3.76 ± 1.1 | 4.62 ± 1.0 | 4.51 ± 1.0 | 4.11 ± 1.0 |
| ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ||
| ∗∗NS | ∗∗ P = 0.001 | ∗∗ P < 0.001 | ∗∗ P < 0.001 | ∗∗ P < 0.001 | ||
|
| ||||||
| CP middle-dose | 2.13 ± 0.8 ∗∗NS | 2.47 ± 0.8 | 3.27 ± 0.9 | 3.87 ± 1.2 | 3.81 ± 1.1 | 3.60 ± 1.2 |
| ∗NS | ∗ P = 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ||
| ∗∗NS | ∗∗NS | ∗∗ P < 0.001 | ∗∗ P < 0.001 | ∗∗ P < 0.008 | ||
|
| ||||||
| CP higher-dose | 2.46 ± 0.6 ∗∗NS | 2.68 ± 0.9 | 3.65 ± 0.9 | 4.07 ± 1.0 | 3.97 ± 0.8 | 4.08 ± 1.2 |
| ∗NS | ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ||
| ∗∗NS | ∗∗ P < 0.001 | ∗∗ P < 0.001 | ∗∗ P < 0.001 | ∗∗ P < 0.001 | ||
|
| ||||||
| COL lower-dose | 2.68 ± 0.6 ∗∗NS | 3.24 ± 1.0 | 3.58 ± 1.1 | 4.13 ± 1.2 | 4.17 ± 1.0 | 4.07 ± 1.1 |
| ∗ P = 0.008 | ∗ P < 0.002 | ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ||
| ∗∗ P = 0.01 | ∗∗ P = 0.006 | ∗∗ P < 0.001 | ∗∗ P < 0.001 | ∗∗ P < 0.001 | ||
|
| ||||||
| COL middle-dose | 2.41 ± 0.8 ∗∗NS | 3.03 ± 0.8 | 3.62 ± 1.2 | 3.80 ± 0.9 | 3.96 ± 1.5 | 4.27 ± 1.2 |
| ∗ P < 0.003 | ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ||
| ∗∗ P = 0.015 | ∗∗ P = 0.003 | ∗∗ P < 0.001 | ∗∗ P = 0.004 | ∗∗ P < 0.001 | ||
|
| ||||||
| COL higher-dose | 2.75 ± 0.8 ∗∗NS | 4.13 ± 1.1 | 4.77 ± 1.2 | 4.40 ± 1.5 | 5.00 ± 1.4 | 5.09 ± 1.5 |
| ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ||
| ∗∗ P < 0.001 | ∗∗ P < 0.001 | ∗∗ P < 0.001 | ∗∗ P < 0.001 | ∗∗ P < 0.001 | ||
|
| ||||||
| AraC lower-dose | 2.20 ± 1.2 ∗∗NS |
2.93 ± 1.5 | 3.45 ± 1.1 | 3.25 ± 1.3 | 2.78 ± 1.5 | 2.24 ± 1.1 |
| ∗ P = 0.080 | ∗ P = 0.008 | ∗ P = 0.017 | ∗NS | ∗NS | ||
| ∗∗NS | ∗∗ P = 0.02 | ∗∗ P = 0.046 | ∗∗NS | ∗∗NS | ||
|
| ||||||
| AraC middle-dose | 2.62 ± 1.2 ∗∗NS | 3.40 ± 1.5 | 3.75 ± 1.1 | 3.78 ± 1.5 | 3.28 ± 1.8 | 3.23 ± 1.6 |
| ∗ P = 0.007 | ∗ P = 0.002 | ∗ P = 0.006 | ∗ P = 0.036 | ∗NS | ||
| ∗∗ P = 0.029 | ∗∗ P = 0.01 | ∗∗ P = 0.003 | ∗∗NS | ∗∗NS | ||
|
| ||||||
| AraC higher-dose | 2.55 ± 0.6 ∗∗NS | 4.14 ± 1.9 | 3.72 ± 1.5 | 3.36 ± 0.9 | 3.33 ± 1.0 | 3.44 ± 1.6 |
| ∗ P < 0.001 | ∗ P = 0.004 | ∗ P < 0.001 | ∗ P = 0.005 | ∗ P < 0.041 | ||
| ∗∗ P = 0.003 | ∗∗ P = 0.012 | ∗∗ P = 0.001 | ∗∗ P = 0.023 | ∗∗NS | ||
Data (‰) expressed as mean ± standard deviation per group of MNEs/1,000 TEs. MNEs: micronucleated erythrocytes, TEs: total erythrocytes, h: hours, and NS: not significant. ∗Intragroup comparisons. ∗∗Intergroup comparisons between negative control groups versus the other groups.