Table 4.
MNPCE frequencies from pup samples of rat study groups at different sampling times.
| Groups | 0 h | 24 h | 48 h | 72 h | 96 h | 120 h |
|---|---|---|---|---|---|---|
| Negative control | 3.75 ± 1.6 | 3.80 ± 1.6 | 4.15 ± 1.8 | 4.30 ± 1.9 | 4.30 ± 1.4 | 4.25 ± 1.4 |
| ∗NS | ∗NS | ∗NS | ∗NS | ∗NS | ||
|
| ||||||
| CP lower-dose | 3.75 ± 1.8 ∗∗NS | 5.00 ± 2.4 | 6.80 ± 2.1 | 7.75 ± 2.3 | 7.75 ± 2.1 | 7.45 ± 2.2 |
| ∗ P = 0.015 | ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ||
| ∗∗NS | ∗∗ P = 0.001 | ∗∗ P < 0.001 | ∗∗ P < 0.001 | ∗∗ P < 0.001 | ||
|
| ||||||
| CP middle-dose | 3.00 ± 1.3 ∗∗NS | 4.80 ± 1.8 | 6.70 ± 2.5 | 7.75 ± 3.5 | 9.30 ± 4.3 | 7.65 ± 3.9 |
| ∗ P = 0.006 | ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ||
| ∗∗NS | ∗∗ P = 0.005 | ∗∗ P = 0.004 | ∗∗ P < 0.001 | ∗∗ P = 0.009 | ||
|
| ||||||
| CP higher-dose | 3.60 ± 1.5 ∗∗NS | 5.35 ± 2.3 | 7.40 ± 3.7 | 9.70 ± 4.2 | 8.70 ± 3.3 | 7.00 ± 3.4 |
| ∗ P = 0.003 | ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ||
| ∗∗NS | ∗∗ P = 0.002 | ∗∗ P < 0.001 | ∗∗ P = 0.015 | ∗∗ P = 0.015 | ||
|
| ||||||
| COL lower-dose | 4.45 ± 1.4 ∗∗NS | 4.80 ± 2.0 | 6.65 ± 2.9 | 7.15 ± 2.7 | 6.90 ± 2.4 | 7.25 ± 2.9 |
| ∗NS | ∗ P < 0.001 | ∗ P < 0.002 | ∗ P = 0.001 | ∗ P = 0.001 | ||
| ∗∗NS | ∗∗ P = 0.016 | ∗∗ P = 0.003 | ∗∗ P = 0.002 | ∗∗ P = 0.002 | ||
|
| ||||||
| COL middle-dose | 4.60 ± 1.9 ∗∗NS | 5.40 ± 2.5 | 7.40 ± 3.9 | 6.85 ± 3.3 | 7.10 ± 2.2 | 6.75 ± 3.4 |
| ∗NS | ∗ P = 0.002 | ∗ P = 0.001 | ∗ P < 0.001 | ∗ P = 0.017 | ||
| ∗∗ P = 0.045 | ∗∗ P < 0.013 | ∗∗NS | ∗∗ P < 0.001 | ∗∗NS | ||
|
| ||||||
| COL higher-dose | 4.80 ± 1.6 ∗∗NS | 6.70 ± 2.7 | 7.50 ± 2.0 | 6.70 ± 1.9 | 7.95 ± 3.2 | 7.25 ± 2.6 |
| ∗NS | ∗ P = 0.003 | ∗ P < 0.001 | ∗ P = 0.001 | ∗ P = 0.001 | ||
| ∗∗ P = 0.004 | ∗∗ P = 0.001 | ∗∗ P = 0.002 | ∗∗ P = 0.001 | ∗∗ P = 0.001 | ||
|
| ||||||
| AraC lower-dose | 2.50 ± 1.2 ∗∗NS | 5.1 ± 2.7 | 9.60 ± 5.6 | 7.10 ± 5.7 | 6.25 ± 2.9 | 2.95 ± 1.4 |
| ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ∗ P = 0.002 | ∗NS | ||
| ∗∗NS | ∗∗ P = 0.002 | ∗∗NS | ∗∗NS | ∗∗ P = 0.033 | ||
|
| ||||||
| AraC middle-dose | 2.65 ± 1.2 ∗∗NS | 4.55 ± 1.3 | 7.95 ± 3.3 | 7.65 ± 3.2 | 5.30 ± 2.4 | 5.15 ± 2.5 |
| ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ||
| ∗∗NS | ∗∗ P = 0.001 | ∗∗ P = 0.005 | ∗∗NS | ∗∗NS | ||
|
| ||||||
| AraC higher-dose | 2.75 ± 1.4 ∗∗NS | 7.10 ± 3.4 | 8.75 ± 3.0 | 6.45 ± 1.8 | 5.25 ± 2.3 | 4.00 ± 2.6 |
| ∗ P < 0.001 | ∗ P < 0.001 | ∗ P = 0.001 | ∗ P < 0.001 | ∗NS | ||
| ∗∗ P = 0.001 | ∗∗ P < 0.001 | ∗∗ P = 0.004 | ∗∗NS | ∗∗NS | ||
Data (‰) expressed as mean ± standard deviation per group of MNPCEs/1,000 PCEs. MNPCEs: micronucleated polychromatic erythrocytes, PCEs: polychromatic erythrocytes, h: hours, and NS: not significant. ∗Intragroup comparisons. ∗∗Intergroup comparisons between negative control groups versus the other groups.