Table 5.
PCE frequencies of pup samples of rat study groups at the different sampling times.
| Groups | 0 h | 24 h | 48 h | 72 h | 96 h | 120 h |
|---|---|---|---|---|---|---|
| Negative control | 608.8 ± 160.7 | 430.7 ± 86.8 | 373.9 ± 89.1 | 375.4 ± 100.5 | 389.0 ± 71.9 | 394.9 ± 67.2 |
| ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ||
|
| ||||||
| CP lower-dose | 605.0 ± 138.7 ∗∗NS | 432.7 ± 91.6 | 397.1 ± 68.1 | 413.7 ± 89.7 | 405.2 ± 81.5 | 401.3 ± 70.9 |
| ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ||
| ∗∗NS | ∗∗NS | ∗∗NS | ∗∗NS | ∗∗NS | ||
|
| ||||||
| CP middle-dose | 618.8 ± 120.6 ∗∗NS | 413.6 ± 94.4 | 338.7 ± 80.7 | 342.6 ± 53.6 | 362.5 ± 59.0 | 399.2 ± 82.1 |
| ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ||
| ∗∗NS | ∗∗NS | ∗∗NS | ∗∗NS | ∗∗NS | ||
|
| ||||||
| CP higher-dose | 632.6 ± 138.0 ∗∗NS | 457.0 ± 100.5 | 379.3 ± 80.6 | 352.3 ± 81.9 | 379.9 ± 55.3 | 388.7 ± 92.0 |
| ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ||
| ∗∗NS | ∗∗NS | ∗∗NS | ∗∗NS | ∗∗NS | ||
|
| ||||||
| COL lower-dose | 621.1 ± 129.7 ∗∗NS | 490.0 ± 95.5 | 391.5 ± 79.9 | 407.3 ± 63.1 | 415.3 ± 69.3 | 441.6 ± 66.4 |
| ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ||
| ∗∗NS | ∗∗NS | ∗∗NS | ∗∗NS | ∗∗NS | ||
|
| ||||||
| COL middle-dose | 571.6 ± 138.2 ∗∗NS | 468.6 ± 94.6 | 389.2 ± 56.2 | 380.7 ± 119.2 | 396.7 ± 54.1 | 419.8 ± 77.8 |
| ∗ P = 0.001 | ∗ P < 0.001 | ∗ P = 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ||
| ∗∗NS | ∗∗NS | ∗∗NS | ∗∗NS | ∗∗NS | ||
|
| ||||||
| COL higher-dose | 667.2 ± 73.5 ∗∗NS | 483.2 ± 114.5 | 392.5 ± 61.4 | 429.5 ± 58.6 | 457.5 ± 63.0 | 440.5 ± 65.2 |
| ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ||
| ∗∗NS | ∗∗NS | ∗∗NS | ∗∗ P = 0.011 | ∗∗NS | ||
|
| ||||||
| AraC lower-dose | 606.2 ± 133.8 ∗∗NS | 344.8 ± 102.0 | 373.9 ± 72.0 | 391.9 ± 70.3 | 392.8 ± 61.8 | 433.5 ± 62.3 |
| ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ||
| ∗∗ P = 0.030 | ∗∗NS | ∗∗NS | ∗∗NS | ∗∗NS | ||
|
| ||||||
| AraC middle-dose | 555.8 ± 106.9 ∗∗NS | 393.8 ± 89.4 | 327.2 ± 49.4 | 381.9 ± 87.8 | 439.6 ± 78.1 | 498.3 ± 81.1 |
| ∗ P = 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ∗ P = 0.024 | ||
| ∗∗NS | ∗∗NS | ∗∗NS | ∗∗NS | ∗∗ P < 0.001 | ||
|
| ||||||
| AraC higher-dose | 535.5 ± 153.7 ∗∗NS | 404.8 ± 73.6 | 361.2 ± 65.0 | 335.2 ± 60.7 | 386.9 ± 77.2 | 424.9 ± 102.0 |
| ∗ P = 0.001 | ∗ P < 0.001 | ∗ P < 0.001 | ∗ P = 0.004 | ∗ P = 0.030 | ||
| ∗∗NS | ∗∗NS | ∗∗NS | ∗∗NS | ∗∗NS | ||
Data (‰) expressed as mean ± standard deviation per group of PCEs/1,000 TEs. PCEs: polychromatic erythrocytes, TEs: total erythrocytes, h: hours, and NS: not significant. ∗Intragroup comparisons. ∗∗Intergroup comparisons between negative control groups versus the other groups.