Figure 4.

14-day TM (1 g/kg) administration suppressed tumor growth in HepG2-xenografted nude mouse models. (a) Tumor-possessing nude mice and (b) tumor tissues separated from CTRL and TM-treated groups. (c) Tumor volumes were measured every other day. Tumor size in the curve is expressed as mean ± SD (n = 3). ^∗ P < 0.05 and ^∗∗ P < 0.01 versus control group. (d) Mean (±SD) body weight of TM-treated and CTRL group (n = 3). (e) TM robustly enhanced the expressions of cleaved-PARP, Bad, and Bax in tumor tissues. Quantification data of protein expressions were normalized by corresponding GAPDH and the average fold of band intensity was marked, respectively (n = 3). (f) The histopathological examination of liver in tumor mouse models.