FIG. 1.

Predicted SARS-CoV replicase gene organization, mature proteins, and antibodies. The location of the SARS-CoV replicase gene in the genome is depicted, with ORF1a and ORF1b shown. The protein domains of polyprotein 1a (pp1a) and the frameshift-fusion polyprotein 1ab (pp1a/b) are shown. Protein domains are indicated by vertical bars, by nonstructural protein number (nsp), and by activities or putative or known functions. The processing of the replicase polyprotein is mediated by two proteinases, the PLP and the 3CL-pro. Black rectangles below proteins indicate regions cloned and expressed as proteins for induction of antibodies (numbers 231 to 265).