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. 2016 Nov 28;2016:1698379. doi: 10.1155/2016/1698379

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Copyright © 2016 Jinpei Lin et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Regulation of mRNA expressions of antioxidant enzymes including HO-1, γ-GCS, and SOD via an Nrf2 dependent mechanism. PF of all three dosages significantly increased the total amount of mRNA expression of antioxidant enzymes by means of upregulating ATF-4 (a) and Nrf2 (b) mRNA expressions as well as HO-1 (c), SOD (d), and γ-GCS (e) in the lung tissue. ^∗ P < 0.05, ^∗∗ P < 0.01, compared with the Normal Control group. ^# P < 0.05, ^## P < 0.01, compared with the COPD group. ^∧ P < 0.05, ^∧∧ P < 0.01, compared with Budesonide group.