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Changes in expression levels of genes involved in ECM remodeling one week after MI. Large changes in expression are demonstrated by arrows (↑ = 2–20x increase, ↑↑ = 20–50x increase.
| Gene name | Beads | Beads-MSC | Beads-MSC-GLP-1 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Infarct | Border | Remote | Infarct | Border | Remote | Infarct | Border | Remote | |
| Col1a1 | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | |||
| Col3a1 | ↑ | ||||||||
| TIMP1 | ↑ | ↑ | ↑ | ↑ | |||||
| TIMP2 | ↑ | ↑ | ↑↑ | ↑ | ↑ | ||||
| MMP2 | ↑ | ↑ | ↑ | ||||||
| MMP9 | ↓ | ↑↑ | ↓↓ | ↓ | ↓ | ↑ | |||
| TGF-β | ↑ | ↑ | |||||||
