Table 3.
Changes in expression levels of genes involved in ECM remodeling four week after MI. Large changes in expression are demonstrated by arrows (↑ = 2–20x increase, ↑↑ = 20–50x increase, and ↑↑↑ = >50x change). Significance is denoted in brackets.
| Gene name | Beads | Beads-MSC | Beads-MSC-GLP-1 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Infarct | Border | Remote | Infarct | Border | Remote | Infarct | Border | Remote | |
| Col1a1 | ↑↑↑ | ↑↑↑ | ↑ | ↑ | ↑↑ | ↑↑ | ↑ | ||
| Col3a1 | ↑↑ (∗∗) | ↑ | ↑ | ↑ | |||||
| TIMP1 | ↑ (∗) | ↑ (∗) | ↑ | ↑ | ↑ | ↑ | ↑ | ||
| TIMP2 | ↑ | ↑ (∗) | ↑ | ↑ | ↑ | ↑ | |||
| MMP2 | ↑↑↑ | ↑↑↑ | ↑↑ | ↑ | ↑ | ||||
| MMP9 | ↑↑↑ | ↑↑↑ | ↑↑ | ↑ | ↑ | ↓ | |||
| TGF-β | ↑↑↑ | ↑ ↑ ↑ (∗) | ↑↑ | ↑ | ↑ | ||||