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. 2016 Nov 27;2016:3974648. doi: 10.1155/2016/3974648

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Copyright © 2016 Nara Lins et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Stereological estimate of total microglia (CA1 total) and on CA1 lacunosum molecular (Lac-Mol) and radiatum and pyramidal layers. Note that as compared to all other groups, Piry (Py) virus infections in combination with intracerebral injection of ME7 infected brain homogenate (ME7+Py), significantly increased the number of microglia in all layers. Normal brain homogenate intracerebrally (i.c.) injection (NBH); NBH i.c. injection and virus suspension instilled intranasally (NBH+Py); ME7 infected brain homogenate (ME7). ∗ indicates significant differences between ME7+Py and all other groups and layers (one-way ANOVA, p < 0.01), and # indicates p < 0.05. Two-way ANOVA revealed that virus infection interacts with prion disease and exacerbates microglial response (p = 0.01).