FIG. 5.

Alignment of HRV3, HRV14, HRV15, and HRV16 sequences in the vicinity of the virus-receptor contact areas. The amino acid sequence of HRV14 is closely similar to that of HRV3, as is the sequence of HRV16 to HRV15. The secondary structural elements are shown above the sequences. The “puff” region is a flexible external loop in VP2 (44). Residues in the virus-receptor interface are highlighted with colors based on the residue property. Basic (blue), acidic (red), polar (green), and hydrophobic (yellow) residues are shown. Residues that are involved in forming ionic networks are indicated by the cyan letters of A, B, C, and D, corresponding to the notation used in Fig. 3 and Table 6.