FIG. 4.
Cycling CD4+ and CD8+ T cells within TN, TCM, and TEM in blood and secondary lymphoid organs. (A) Backgating of Ki-67-positive cells (darker dots) on CD28+ and CD95+ T cells. Arrows indicate memory-like cells within the CD4+ T-cell compartment. Axillary lymph nodes were collected 2 days after discontinuation of IL-7 treatment from all macaques in the study, and the histograms (on the left) represent the mean percentages of Ki-67-positive CD4+ and CD8+ T cells in lymph nodes of animals in each group. (B) Percentages of Ki-67-positive CD8+ T cells are shown in the left panel for lymph nodes for all animals. Right panels show blood or lymph node samples of animals treated with each dose of IL-7.