TABLE 5.
Elution of His6-tagged retrovirus vectors under different pHs
Fraction (3 ml) | Viral titer (105 CFU/ml) | Proteins (mg/ml) | DNA (μg/ml) |
---|---|---|---|
Feed | 4.2 | 7.72 | 0.16 |
Flowthrough | 0.03 | 2.13 | 0.11 |
pH 7.3a | 0 | 0.89 | 0.059 |
pH 6.5 | 0 | 1.11 | <2.5 × 10−5 |
pH 6.0 | 0 | 1.02 | <2.5 × 10−5 |
pH 5.5 | 0 | 0.57 | <2.5 × 10−5 |
pH 5.0 | 0 | 0.15 | <2.5 × 10−5 |
The pH value of the elution buffer.