TABLE 2.
Animals used in this study
| Animal | MHC class I genotypea | Virusb | Peak virus loadc (106 copies/ml) | Setpoint virus loadd (106 copies/ml) |
|---|---|---|---|---|
| B | A*01 A*02 B*17 B*29 | Wild type | 4.6 | 0.0515 |
| D | A*02 | 3× | 13.0 | 4.6e |
| E | A*01 A*11 B*01 B*17 B*29 | 3× | 4.7 | 1.3 |
| F | A*01 A*11 B*17 B*29 | 3× | 4.1 | 0.0096 |
| G | A*01 A*02 B*17 B*29 | 3× | 3.4 | 0.0244 |
| H | A*01 B*17 B*29 | 3× | 1.6 | 0.0006 |
a
Animals were typed for Mamu-A*01, -A*02, -A*08, -A*11, -B*01, -B*03, -B*04, -B*17, and-B*29 by PCR with sequence-specific primers (PCR-SSP) as described in Materials and Methods. The alleles listed gave positive results in replicate PCR-SSP assays.
b
Animals were inoculated intravenously with 100 50% tissue culture infections doses of wild-type SIVmac239 or epitope mutant SIVmac239 (3×).
c
Virus loads are shown as viral RNA copies per milliliter of plasma, as determined by the branched-chain DNA assay, and were reported previously (9).
d
Geometric mean virus load between 12 and 40 weeks postinfection, based on ≥5 separate time points.
e
Animal D died 30 weeks postinfection.