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. 2016 Dec 12;6:38619. doi: 10.1038/srep38619

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Copyright © 2016, The Author(s)

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Spleens and splenic lymphocytes were isolated from B6.Nrf2^−/−lpr/lpr, B6/lpr, B6.Nrf2^−/−, and WT B6 mice at 6 months old (n = 9) and 3 months old (n = 7) and counted, then analysed by flow cytometry. (a) The spleens of the Nrf2^−/−lpr/lpr mice were the largest in comparison with those of other genotypes of mice at 6 months old. (b) The total number of lymphocytes in the B6.Nrf2^−/−lpr/lpr mice were increased at both 3 and 6 months. The proportion of CD3⁺CD4⁺ T cells was significantly increased in the B6.Nrf2^−/−lpr/lpr mice compared with that in the B6.lpr mice (c). (d) At 6 months of age, in the B6.Nrf2^−/−lpr/lpr mice, the proportions of CD3⁺CD4⁺ T cells and CD3⁺CD8⁺ T cells among splenic lymphocytes were higher than those in the other mouse genotypes. The Nrf2^−/−lpr/lpr mice had more B cells in spleen (e). Data values represent mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001.