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. 2016 Dec 12;6:38792. doi: 10.1038/srep38792

Figure 4. EphB4 targeting enhances radiosensitivity in HNSCC PDX models.

Figure 4

Tumor growth analyses of CUHN013 PDX tumors (A,B), CUHN022 PDX tumors (C,D), and CUHN004 PDX tumors (E,F) show that sEphB4-HSA treatment combined with radiation significantly decreases tumor volume over time compared to single agent treatments. sEphB4-HSA was administered on days 0, 3, 5, 7, 10, 12, 14, 17, 19, 21, 24, 26, 28, 31, 33, 35, and 38. The symbol “↓” represent days when tumors were exposed to ionizing radiation (5 Gy/fraction for CUHN013 and CUHN004; 2 Gy/fraction for CUHN022). The mice in the PBS group were sacrificed on day 31 (CUHN013), or day 28 (CUHN004) because their tumors became too large. Data shown represent mean ± standard deviation. *p < 0.05,**p < 0.005, **p < 0.0005.