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. 2016 Dec 12;6:38792. doi: 10.1038/srep38792

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Western blot analysis shows decreased phosphorylation or decreased levels of proteins implicated in tumor growth and cell survival in CUHN013 tumors treated with sEphB4-HSA and radiation compared to tumors treated with a single agent. (B) A heat map generated based on the results of a human apoptosis antibody array using GeneE software (Broad institute, USA) depicts decreased expression of survival markers in CUHN013 tumors treated as indicated. (C) Validation of hits by western blotting shows decreased levels of pro-survival proteins such as Ho-2, Bcl-2, and survivin in tumors treated with sEphB4-HSA combined with radiation (XRT) compared to tumors treated with a single agent.