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Repression by CAR and PXR of FOXO1-IRS activity. The IRS-tk-Luc reporter and pcDNA3/mFOXO1 were cotransfected with pCR3/mCAR (a) or pcDNA3/mPXR (b) into HepG2 cells. In some cases, pCMX/hRXR was additionally transfected. Relative activities were calculated by taking the activity of the cells that were transfected by only the reporter plasmid in the presence of DMSO as one. Bars indicate means ± standard deviations.
