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Identification of GAP activity-essential asparagines corresponding to mutations found in TSC patients. (A) Asparagine residues N1601, N1609, and N1639 are essential for TSC2 GAP activity. The GTP-to-GDP ratio of Rheb was measured in the presence of wild-type and mutant TSC2 as indicated. (B) Alignment of TSC2 mutated residues described above (A). fugu, Fugu rubripes; pombe, S. pombe.
