Table 1. Clinical characteristics of responders and non-responders.
| Responders (n = 17) | Non-responders (n = 75) | |||
|---|---|---|---|---|
| Gender (M/F) | 10/7 | 58/17 | ||
| Age, years | 27 (19–42) | 28 (19–45) | ||
| HBV genotype B/C | 8/9 | 37/38 | ||
| Baseline | End of follow-up | Baseline | End of follow-up | |
| HBV-DNA, Log10IU/mL | 8.1 ± 7.7 | 2.5 ± 2 | 8.5 ± 8.3 | 7.9 ± 7.2 |
| HBsAg, IU/mL | 14,091 ± 3,595 | 2,142 ± 823 | 22,175 ± 3,278 | 12,540 ± 1,705 |
| Anti-HBsAg positive | 0/17 (0%) | 0/17 (0%) | 0/75 (0%) | 0/75 (0%) |
| HBeAg, COI | 429.2 ± 113.8 | 0.24 ± 0.059* | 6,162 ± 1,371 | 404.8 ± 60.6 |
| Anti-HBeAg positive | 0/17 (0%) | 17/17 (100%) | 0/75 (0%) | 27/75 (36%) |
| Anti-HBcAg positive | 17/17 (100%) | 17/17 (100%) | 75/75 (100%) | 75/75 (100%) |
| ALT, U/L | 217 (80–580) | 21 (10–33) | 218 (75–530) | 124 (19–1107) |
| AST, U/L | 108 (50–244) | 30 (19–49) | 117 (24–346) | 39 (17–141) |
*HBeAg negative was defined as HBeAg <1 COI. Unless otherwise indicated, values are median (range). Values for HBV-DNA, HBsAg, and HBeAg are median ± SEM. ALT, alanine aminotransferase; AST, aspartate aminotransferase; HBV, hepatitis B virus; HBsAg, hepatitis B surface antigen; HBeAg, hepatitis B envelope antigen; COI, cutoff index.