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. 2016 Nov 15;59(23):10705–10718. doi: 10.1021/acs.jmedchem.6b01410

Scheme 5.

Scheme 5

Reagents and conditions: (a) Cu(OAc)2, MeOH, O2, 70 °C; 12 h; (b) Cu(OAc)2, pyridine, CH2Cl2, rt, 7 d.