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. 2016 Nov 15;59(23):10705–10718. doi: 10.1021/acs.jmedchem.6b01410

Scheme 6.

Scheme 6

Reagents and conditions: (a) 1–2 M NaOH, 0 °C to rt, 3–12 h; (b) 2–4 M HCl, 110 °C, 2–12 h.