Table 3. Average Cell Growth Inhibition Data for Compounds 14 and 16–18 (GI₅₀, μM) against a Panel of 60 Human Cancer Cells.

	average cell growth inhibition (GI50, μM)a
cell type (number of cell lines)	ABT-199	(±)-gossypol	14	16	17	18
leukemia (6)	2.11	2.47	1.88	0.56	0.81	1.03
nonsmall cell lung cancer (9)	2.7	2.85	1.65	0.48	1.05	1.51
colon cancer (7)	2.85	3.19	1.63	0.46	1.00	1.44
cns cancer (6)	3.35	2.97	1.63	0.60	1.27	1.46
melanoma (9)	1.75	3.22	2.84	0.99	1.42	2.35
ovarian cancer (7)	3.33	3.50	1.74	0.59	1.26	2.65
renal cancer (8)	2.6	3.16	2.19	0.82	1.14	2.08
prostate cancer (2)	3.51	NDb	1.92	0.41	1.09	1.41
breast cancer (6)	2.77	ND	2.44	0.74	1.08	1.72

^aGI₅₀: concentration required for 50% cell growth inhibition.

^bND: not determined.