Scheme 1.
Reagents and conditions: (a) 3-fluoro-5-methoxyphenylboronic acid (4), Na2CO3, Pd(PPh3)4, DMF, H2O, 75 °C, 2 h, 32%; (b) i. NaH, DMF, 0 °C-RT, ii. R-OMs, 80 °C, 2 h, 5–50%; (c) 1 M BBr3 in CH2Cl2, 0 °C, 18 h, 3–50%.
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