Table 3. In Vivo Mouse Pharmacokinetic Properties^a of Initial Hits.

No.	CL (L/h/kg)	Vz (L/kg)	AUCPO (μM·h)	PO t1/2 (h)	F (%)
9b	5.10	6.01	0.177	3.1	2.2
15b	9.36	11.5	0.033	0.60	0.8
16b	7.29	5.45	0.211	0.80	3.7
18c	3.82	5.90	0.213	2.3	6.9
20b	1.87	6.56	2.37	6.3	11
21b	9.25	12.1	0.073	0.95	1.7

^aWinNonlin noncompartmental analysis.

^bDosed 5 mg/kg IV and 15 mg/kg PO.

^cDosed 1 mg/kg IV and 5 mg/kg PO.