Table 7. Biochemical and in Vitro ADME Results for (+)-32 and (−)-32.

	kinase selectivity (ratio)					in vitro metabolismd (%R)
No.	PI3Kαa	PI3Kβa	PI3Kγa	BMXb	TECc	hLM	mLM	rLM	dLM	hUGT	mUGT	Caco-2e	PPBf (%)
(+)-32	6	34	2	4	20	71	28	45	65	91	93	1.3	98
(−)-32	17	44	7	1	7	63	11	46	32	91	99	1.7	98

^aRatio of PI3K IC₅₀/PI3Kδ IC₅₀.

^bRatio of BMX IC₅₀/BTK IC₅₀.

^cRatio of TEC IC₅₀/BTK IC₅₀.

^dPercent parent remaining (%R) after 30 min.

^eEfflux ratio, P_appB → A/P_appA → B.

^fPercent mouse plasma protein binding (PPB).