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. 2016 Oct 28;7(12):1161–1166. doi: 10.1021/acsmedchemlett.6b00356

Table 8. In Vivo Mouse Pharmacokinetic Propertiesa of 32b.

No. CL (L/h/kg) Vz (L/kg) AUCPO (μM·h) PO t1/2 (h) F (%)
(+)-32 1.46 0.58 9.28 1.2 57
(−)-32 0.59 3.44 15.2 1.3 40
a

WinNonlin noncompartmental analysis.

b

Dosed 2 mg/kg IV and 10 mg/kg PO.