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. 2016 Sep 28;7(12):1024–1027. doi: 10.1021/acsmedchemlett.6b00180

Figure 2.

Figure 2

(A) Competitive binding of triptophenolide to the AR-LBD evaluated by AR fluorescence polarization (FP) assay. (B) The inhibition curves of triptophenolide and ENZ. (C) Triptophenolide (in stick, carbon in gray) fits the HBP of AR quit well in the predicted binding mode. (D) The detail interactions between triptophenolide and AR, hydrogen bond is indicated by the black dashed line with arrow. Experiments were in triplicate. *P < 0.05, ** P < 0.01, *** P < 0.001 vs control group. All results are shown as mean ± SD.