Table 1. Inhibition Data for Compounds 11–20 (K_i in nM).

inhibitor	rhodesain (RD)	cruzain (CRZ)	cathepsin B (CB)	cathepsin L (CL)
11	0.49	0.44	8	11
12	6.5	16	68	30
13	29	130	310	110
14	4.2	11	34	19.6
15	50	NDa	6300	280
16	30	130	310	200
17	18.4	25	210	46
18	18	28	710	49
19	14	17	72	27
20	544	ND	3200	2020
K11777b	20	ND	390	80

^aND = Not determined.

^bk_second values [M^–1 s^–1] for inhibition by K11777: RD: 6.6 × 10⁵; CL: 9.2 × 10⁵; CB: 2.3 × 10⁴.