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. 2016 Dec 12;6:38868. doi: 10.1038/srep38868

Figure 2. VAN induced AKI is attenuated in p53-KO mice.

Figure 2

Wild-type and p53-KO littermate mice were injected with 400 mg/kg VAN (n = 8) or saline as control for 7 days. (A and B) Blood samples were collected for measurements of BUN and serum creatinine levels. (C) Kidneys were collected for immunoblot analysis of p53 and ß-actin. (D) Immunohistochemical staining of p53, Bar: 100 μM. (E) Tubular damage in VAN treated cortical tissues was semiquantified as pathologic scores. Data were expressed as means ± SD; the bars with different superscripts (a–c) in each panel were significantly different (P < 0.05). Data are representative of at least four separate experiments.