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. 2016 Dec 12;6:38868. doi: 10.1038/srep38868

Figure 4. MiR192-5p expression is suppressed in p53 KO mice.

Figure 4

Wild-type and p53-KO littermate mice were injected with 400 mg/kg VAN (n = 8) or saline as control for 0–7 days. Whole tissue lysate was analyzed for miR192–5p and U6 by Real-time PCR or Northern blot. (A) Real-time PCR showed the time-course of miR-192-5p expression levels in VAN induced AKI. (B) Real-time PCR showed miR192-5p expression is reduced in p53 KO mice. (C) Representative Northern blot analysis. (D) Northern blot signals were quantified by densitometry, and normalized with U6. Data were expressed as means ± SD; the bars with different superscripts (a–c) in each panel were significantly different (P < 0.05). Data are the representative of at least four separate experiments.