Table 3. Cell proliferation assessed by BrdUrd uptake in the coronal suture and in each side of the basisphenoid—basioccipital synchondrosis.
| BrdUrd uptake, %
|
||||
|---|---|---|---|---|
| Suture | Genotype | E14.5 | E16.5 | P1 |
| Coronal | Wild type | 35 ± 1 | 20.4 ± 1.61 | 55.6 ± 3.1 |
| Fgfr2cC342Y/+ | 39.6 ± 1.02* | 20.1 ± 1.7 | 48.76 ± 2.7 | |
| Basisphenoid | Wild type | 14.08 ± 1 | 2.44 ± 0.04 | 4.34 ± 0.53 |
| Fgfr2cC342Y/+ | 3.79 ± 0.3† | 3.58 ± 3.58 | 5.98 ± 0.6 | |
| Basioccipital | Wild type | 9.07 ± 0.8 | 2.96 ± 0.3 | 4.44 ± 0.77 |
| Fgfr2cC342Y/+ | 5.56 ± 0.7‡ | 2.7 ± 0.28 | 5.75 ± 0.6 | |
Numbers represent BrdUrd-positive nuclear area measurements expressed as percentage of the total nuclear area. *, P < 0.05; †, P < 0.0001; ‡, P < 0.005 (Student's t test) compared with wild type.