Table 3. Transmission disequilibrium test results for three- and five-marker haplotypes.
| SNP | Sib study (Caucasian) haplotypes | ||||
|---|---|---|---|---|---|
| 1 | 2 | ||||
| 2 | 1 | 1 | 1 | ||
| 3 | 1 | 1 | 1 | 1 | |
| 4 | 1 | 1 | 1 | 1 | |
| 6 | 1 | 1 | 1 | ||
| 7 | 1 | 1 | |||
| Global P value | 0.23 | 0.05 | 0.01 | 0.01 | 0.006 |
| Best P value | 0.01 | 0.01 | 0.007 | 0.0001 | 0.002 |
| Frequency | 0.29 | 0.57 | 0.62 | 0.61 | 0.53 |
| Transmitted | 14 over | 15 over | 15 over | 18 over | 21 over |
SNP5 is omitted because its frequency is <0.10. “Global P value” refers to 1 χ2 analysis testing for an altered transmission for all common haplotypes. “Best P value” refers to the most significant individual result for a specific haplotype, shown in the table. Because rare haplotypes (<3%) were excluded, they cannot account for this association.