Table 5. Effect of SNP4 genotype on NAA levels in left (L) and right (R) dorsolateral prefrontal cortex (DLPFC).
NAA
|
|||
---|---|---|---|
SNP4 genotype | L DLPFC | R DLPFC | Valid number |
Index A/A | 2.34 (0.34) | 2.39 (0.33) | 49 |
Index A/G | 2.44 (0.38) | 2.35 (0.39) | 47 |
Index G/G | 2.58 (0.50) | 2.68 (0.4.4) | 8 |
sib A/A | 2.40 (0.31) | 2.40 (0.35) | 50 |
sib A/G | 2.40 (0.45) | 2.45 (0.38) | 40 |
sib G/G | 2.42 (0.47) | 2.37 (0.40) | 12 |
Controls A/A | 2.30 (0.26) | 2.22 (0.26) | 23 |
Controls A/G | 2.47 (0.43) | 2.42 (0.37) | 18 |
Controls G/G | 2.99 (0.60) | 2.73 (0.11) | 3 |
All groups | 2.40 (0.38) | 2.39 (0.36) | 250 |
Subjects with an A allele have lower levels than G/G homozygotes. Although we did not see a significant group by genotype interaction, genotype seemed to have little effect in the sibling group. SDs are given in parentheses. Genotype groups were well matched for age, gender, IQ, and education.