Table 2.
Time (h) | Percent dose recovered | ||||
---|---|---|---|---|---|
Liver | Kidney | Lung | Spleen | ||
Rifampicin drug solution | 2 | 24.3 ± 0.3 | 7.5 ± 0.2 | 3.6 ± 0.7 | 2.4 ± 0.3 |
4 | 32.7 ± 0.5 | 8.8 ± 0.7 | 4.9 ± 0.4 | 3.2 ± 0.2 | |
6 | 23.1 ± 0.2 | 6.5 ± 0.6 | 2.9 ± 0.4 | 1.6 ± 0.5 | |
24 | 7.6 ± 0.5 | 3.1 ± 0.2 | Nil | Nil | |
Uncoupled SLNs | 2 | 28.4 ± 1.2 | 5.7 ± 0.4 | 7.1 ± 0.3 | 6.4 ± 0.5 |
4 | 34.8 ± 1.6 | 6.4 ± 0.2 | 15.6 ± 0.6 | 7.3 ± 0.2 | |
6 | 30.5 ± 1.4 | 4.3 ± 0.1 | 6.5 ± 0.2 | 5.2 ± 0.3 | |
24 | 18.4 ± 1.5 | Nil | 2.1 ± 0.5 | 4.6 ± 0.6 | |
Coupled SLNs | 2 | 33.7 ± 1.2 | 4.5 ± 0.4 | 39.3 ± 0.5 | 7.1 ± 0.1 |
4 | 35.5 ± 1.3 | 5.2 ± 0.6 | 47.7 ± 0.4 | 7.6 ± 0.3 | |
6 | 31.6 ± 0.8 | 3.4 ± 0.3 | 42.1 ± 0.4 | 5.2 ± 0.6 | |
24 | 22.4 ± 1.5 | Nil | 35.3 ± 0.2 | 2.5 ± 0.2 |
SD ± mean (n = 3)