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. 2004 Aug 13;101(34):12646–12651. doi: 10.1073/pnas.0403831101

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Copyright © 2004, The National Academy of Sciences

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Fig. 2. — T cell-dependent autoimmune response to CII, but not to OVA, is enhanced in Ncf1-mutated mice. Antibody response directed against (A) CII and (B) epitopes of CII was measured in serum at day 40 after CIA induction in B10.Q.Ncf1*/* (n = 19), B10.Q.Ncf1+/* (n = 28) and B10.Q.Ncf1+/+ (n = 11) mice. A significant difference (P < 0.05) in levels of antibodies against C1, J1, and U1 can be seen between wild-type and homozygously mutated mice. (C) DTH response against CII in B10.Q.Ncf1*/* (n = 17), B10.Q.Ncf1+/* (n = 20) and B10.Q.Ncf1+/+ (n = 7) was evaluated for reactivity 48 h after stimulation with CII in the ear. DTH result is presented as percent volume increase of the stimulated ear in comparison to control injected left ear. A significantly lower response can be seen in B10.Q.Ncf1+/* and B10.Q.Ncf1+/+ compared with B10.Q.Ncf1*/* (P < 0.05). (D) DTH response presented as percent volume increase of the ear stimulated with OVA in comparison with control-injected left ear after 48 h and (E) antibody response measured in sera on day 18 after immunization with OVA in B10.Q.Ncf1+/* (n = 7) and B10.Q.Ncf1*/* (n = 11).