Table 2. Antibacterial Activity of Compounds 11, 12, 19, 22, and 24 against Z172, VRE and Several Gram Negative Bacteria.
| minimum
inhibitory concentration (μg/mL) |
||||||
|---|---|---|---|---|---|---|
| compd | Z172a | ATCC 51299 (VRE) | ATCC 25922 (E. coli) | ATCC 27853 (P. aeruginosa) | ATCC 700603 (K. pneumoniae) | ATCC 19606 (A. baumannii) |
| 11 | 2 | 2 | 8–16 | >64 | >64 | 16 |
| 12 | 2 | 1 | >64 | >64 | >64 | >64 |
| 19 | 1 | 1 | 4 | >64 | >64 | 8 |
| 22 | 1 | 2 | >64 | >64 | >64 | >64 |
| 24 | 4 | 2 | >64 | >64 | >64 | >64 |
| vancomycin | 4 | 8–16 | N.A. | N.A. | N.A. | N.A. |
a
Z172 is a hospital-associated MRSA strain in Taiwan that exhibits vancomycin-intermediate and daptomycin-nonsusceptible phenotypes.