Table 3. Pharmacokinetic Studies of Compound 19 and Vancomycin in Male ICR Mice^a.

compd	route	dose (mg/kg)	Cmax (ng/mL)	T1/2 (h)	CL (mL/min/kg)	Vss (L/kg)	AUC(0–24h) (ng/mL·h)
19	i.v.	10	29667	10.3	6.9	4.9	20546
vancomycin	i.v.	10	58500	0.6	11.7	0.3	13715

^aValues indicate mean (n = 3, per time point). Abbreviations: half-life (T_1/2); total body clearance (CL); volume of distribution at steady-state (V_ss); area under the curve (AUC). C_max was taken at t = 20 min.