Table 2. PR-Antagonistic Activity of N-Substituted Sulfonanilide Derivatives.

compd	R1	R2	IC50 (μM)a
19a	2-Cl	H	0.74 ± 0.057
19c		Me	0.39 ± 0.039
19d		Bn	2.2 ± 0.28
20a	3-Cl	H	0.17 ± 0.038
20c		Me	0.65 ± 0.029
20d		Bn	2.2 ± 0.12
21a	4-Cl	H	0.67 ± 0.020
21c		Me	0.96 ± 0.11
21d		Bn	3.0 ± 0.25
22a	3-OMe	H	0.25 ± 0.017
22c		Me	0.47 ± 0.027
22d		Bn	2.6 ± 0.35
23a	4-OMe	H	0.50 ± 0.17
23c		Me	0.99 ± 0.13
23d		Bn	3.5 ± 0.22

^aExpression of alkaline phosphatase was induced with 1 nM progesterone.