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. 2016 Sep 15;7(12):1028–1033. doi: 10.1021/acsmedchemlett.6b00184

Table 3. PR-Antagonistic Activity of Benzenesulfonanilide Derivatives 20a and 24–32.

graphic file with name ml-2016-00184e_0007.jpg

compd R1 IC50 (μM)a
20a 3-Cl 0.17 ± 0.038
24 2,3-Cl2 0.64 ± 0.72
25 3,4-Cl2 0.41 ± 0.015
26 3,5-Cl2 0.32 ± 0.052
27 2,4,5-Cl3 1.6 ± 0.051
28 3-F 0.22 ± 0.014
29 3-Br 0.11 ± 0.025
30 3-NO2 0.14 ± 0.035
31 3-CN 0.30 ± 0.018
32 3-CF3 0.033 ± 0.003
a

Expression of alkaline phosphatase was induced with 1 nM progesterone.