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ICG-001 binds CBP and inhibits β-catenin/TCF-mediated transcription. (A) Chemical structures of ICG-001 and ICG-002. (B and C) ICG-001 selectively inhibits the β-catenin/TCF reporter construct TOPFLASH but not FOPFLASH. (D) CBP is the molecular target of ICG-001. Nuclear extracts of SW480 cells were incubated with streptavidin-agarose beads coated with ICG-002. Bound proteins were eluted and immunoblotted (4% gel) with anti-CBP antibody (Upper) or silver-stained (Lower).
