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. 2016 Dec 12;7:584. doi: 10.3389/fimmu.2016.00584

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Copyright © 2016 Bettens, Buhler and Tiercy.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mixed lymphocyte reactions (MLRs) between different HLA-C MM stimulators and the same responder. Each panel represents MLRs between responder cells isolated from the same individual and HLA-C MM stimulator cells from two to three different individuals. MLRs of each panel were performed in parallel (i.e., at the same time) for each experiment and represent four different HLA-C MM: the mismatched HLA-C alleles of the responder and the stimulator are indicated below each panel. Alloresponses are given as %ΔCD137⁺CD8⁺ cells (2% cutoff indicated by the dashed line). All pairs were DPB1 incompatible except two pairs [dashed bars in (A,C)]. (E) shows the correlation between HLA-C mRNA expression of the stimulator cells and the induced alloresponse (%ΔCD137⁺CD8⁺ cells): r = 0.42, p = 0.056. Triangles correspond to HLA-DPB1-matched pairs. All other MLRs were HLA-DPB1 mismatched. Colors in (E) correspond to those used in (A–D).