Fig. 4.
Acute pain behavior of Nav1.7R-/- mice. (A) Noxious thermal stimulation of fNav1.7 (white) and Nav1.7R-/- (black) mice by using Hargreave's apparatus. The latency of hindpaw withdrawal was significantly increased in Nav1.7R-/- mice (11.01 ± 0.47, n = 14, and 8.23 ± 0.67, n = 12, respectively) (P = 0.003, t test). (B) Response to noxious thermal stimulation by using the hotplate apparatus was not significantly different in fNav1.7 (n = 12) and Nav1.7R-/- (n = 17) mice (P = 0.27, 0.11, and 0.79, t test). (C)Nav1.7R-/- mice (396.4 ± 4.0, n = 19) showed profound analgesia to noxious mechanical pressure when using the Randall-Selitto apparatus compared with fNav1.7 mice (195.5 ± 4.8, n = 18) (P < 0.0001, t test). (D) Response to mechanical stimulation when using von Frey hairs was not significantly different in fNav1.7 (n = 11) and Nav1.7R-/- (n = 19) mice.